Photographer: Jeroen Oerlemans

prof. dr. M.W.M. (Michiel) van den Brekel

Oncologie gerelateerde stem- en spraakstoornissen (leerstoel in samenwerking met het Nederlands Kanker Instituut)
  • Faculty of Humanities
    Capaciteitsgroep Taalwetenschap
  • Visiting address
    P.C. Hoofthuis
    Spuistraat 134  Amsterdam
    Room number: 630
  • Postal address:
    Spuistraat  134
    1012 VB  Amsterdam
  • M.W.M.vandenBrekel@uva.nl
    T: 0205254884

Interview

Not only is Michiel van den Brekel professor at the Faculty of Humanities, he is also head of the department of Head and Neck Oncology and Surgery at the Netherlands Cancer Institute and a staff member in the department of Otorhinolaryngology at the Amsterdam Academic Medical Centre. Appointed as Professor of Oncology-Related Voice and Speech Disorders in 2011, Van den Brekel is excited about the prospect of helping to further the cooperative relationship between the humanities and medicine.  A fertile ground for cooperation The idea that a university chair with the medical name 'oncology related voice and speech disorders' could form part of a humanities faculty seems counterintuitive, if not downright absurd. Indeed, thinking of medicine and humanities, one is easily excused for viewing these two disciplines as polar opposites, with little or nothing in common. And yet, on closer inspection, the links between them are as strong as they are beneficial; something to which Van den Brekel's own chair attests. Said Van den Brekel: 'Within the ACLC (Amsterdam Center for Language and Communication) there is substantial knowledge about speech, articulation and language, which can be practically applied within head and neck oncology. One of the goals of the research group is to ascertain whether patients can compensate for changes in voice and speech, and if yes, in what way? The ACLC plays a pivotal role in the linguistic side of the rehabilitation process. With the help of speech technology, our aim is to get a more comprehensive insight into the possible consequences an operation might have on a patient, so that we are able to provide better counseling about the various treatment options that are available.' Linking the fields of humanities and medicine  One of Van den Brekel's research fields is oncology related voice and speech disorders, which is a subject area in which the Faculty of Humanities provides unique expertise. Head and neck cancer is the sixth most common type of cancer in the Netherlands, with approximately 3000 patients treated for this disease annually. Van den Brekel: "Many patients with a tumor in their larynx and throat end up with impairments in speech and have difficulty swallowing partly as a result of the treatment. The research into these impairments can be done from both a medical and academic perspective.'  To illustrate the unique role that the humanities can play in oncology, Van den Brekel mentions a research project currently being carried out by one of the Faculty's PhD candidates, whereby speech technology is used for exploring a patient's comprehensibility and quality of voice after oncological treatment. As yet, patients suffering from voice and speech impairment after an operation usually visit a speech therapist, who then gives them exercises to do. In most cases both speech therapist and patient usually believe they're able to detect improvements after a few months of exercise, which is by no means an objective assumption. In this sense speech therapy is still a relatively young science. It would therefore be advantageous to use voice recognition software that automatically measures such things as speech quality, comprehension and all sorts of aspects surrounding articulation. In using such a device, both patient and speech therapist would be better informed about the current stage of rehabilitation and what still needs to be done. This is a process in which linguistic knowledge and techniques can play a major role.  A stimulating environment It is now almost a year since Van den Brekel started working at the Faculty of Humanities, which begs the question: does he feel like a humanities scholar? 'Although I'm a physician above all, I do enjoy working at the Faculty. As a medical practitioner you're mostly confined to a hospital. It's therefore really refreshing to see people at this Faculty engaged in totally different things. My own chair forms a beneficial link between the Faculty of Humanities and the medical world

2017

  • Lansaat, L., van den Boer, C., Muller, S. H., van der Noort, V., van den Brekel, M. W. M., & Hilgers, F. J. M. (2017). Ex vivo humidifying capacity and patient acceptability of stoma cloths in laryngectomized individuals. Head & Neck, 39(5), 921-931. DOI: 10.1002/hed.24708  [details] 
  • Kraaijenga, S. A. C., van der Molen, L., Heemsbergen, W. D., Remmerswaal, G. B., Hilgers, F. J. M., & van den Brekel, M. W. M. (2017). Hyoid bone displacement as parameter for swallowing impairment in patients treated for advanced head and neck cancer. European Archives of Oto-Rhino-Laryngology, 274(2), 597-606. DOI: 10.1007/s00405-016-4029-y  [details] 
  • Lansaat, L., de Kleijn, B. J., Hilgers, F. J. M., van der Laan, B. F. A. M., & van den Brekel, M. W. M. (2017). A prospective multicenter clinical feasibility study of a new automatic speaking valve for postlaryngectomy voice rehabilitation. European Archives of Oto-Rhino-Laryngology, 274(2), 1005-1013. DOI: 10.1007/s00405-016-4304-y  [details] 
  • Kraaijenga, S., van der Molen, L., Stuiver, M. M., Takes, R. P., Al-Mamgani, A., van den Brekel, M. W. M., & Hilgers, F. J. M. (in press). Efficacy of a novel swallowing exercise program for chronic dysphagia in long-term head and neck cancer survivors. Head & Neck.

2016

  • Kraaijenga, S. A. C., Lapid, O., van der Molen, L., Hilgers, F. J. M., Smeele, L. E., & van den Brekel, M. W. M. (2016). Feasibility and potential value of lipofilling in post-treatment oropharyngeal dysfunction. The Laryngoscope, 126(12), 2672-2678. DOI: 10.1002/lary.26003  [details] 
  • Samuels, S. E., Eisbruch, A., Beitler, J. J., Corry, J., Bradford, C. R., Saba, N. F., ... Ferlito, A. (2016). Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma: Where are we? European Archives of Oto-Rhino-Laryngology, 273(10), 2877-2894. DOI: 10.1007/s00405-015-3771-x  [details] 
  • Jacobi, I., Timmermans, A. J., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Voice quality and surgical detail in post-laryngectomy tracheoesophageal speakers. European Archives of Oto-Rhino-Laryngology, 273(9), 2669-2679. DOI: 10.1007/s00405-015-3777-4  [details] 
  • Passchier, E., Stuiver, M. M., van der Molen, L., Kerkhof, S. I. C., van den Brekel, M. W. M., & Hilgers, F. J. M. (2016). Feasibility and impact of a dedicated multidisciplinary rehabilitation program on health-related quality of life in advanced head and neck cancer patients. European Archives of Oto-Rhino-Laryngology, 273(6), 1577-1587. DOI: 10.1007/s00405-015-3648-z  [details] 
  • Clapham, R. P., Martens, J-P., van Son, R. J. J. H., Hilgers, F. J. M., van den Brekel, M. W. M., & Middag, C. (2016). Computing scores of voice quality and speech intelligibility in tracheoesophageal speech for speech stimuli of varying lengths. Computer Speech and Language, 37, 1-10. DOI: 10.1016/j.csl.2015.10.001  [details] 
  • Timmer, F. C. A., Klop, W. M. C., Relyveld, G. N., Crijns, M. B., Balm, A. J. M., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2016). Merkel cell carcinoma of the head and neck: emphasizing the risk of undertreatment. European Archives of Oto-Rhino-Laryngology, 273(5), 1243-1251. DOI: 10.1007/s00405-015-3558-0  [details] 
  • Wondergem, M., Lieben, G., Bouman, S., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2016). Patients' satisfaction with facial prostheses. British Journal of Oral & Maxillofacial Surgery, 54(4), 394-399. DOI: 10.1016/j.bjoms.2015.09.011  [details] 
  • Kraaijenga, S. A. C., Oskam, I. M., van Son, R. J. J. H., Hamming-Vrieze, O., Hilgers, F. J. M., van den Brekel, M. W. M., & van der Molen, L. (2016). Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy. Oral Oncology, 55, 24-30. DOI: 10.1016/j.oraloncology.2016.02.001  [details] 
  • Timmermans, A. J., Harmsen, H. J. M., Bus-Spoor, C., Buijssen, K. J. D. A., van As-Brooks, C., de Goffau, M. C., ... van der Laan, B. F. A. M. (2016). Biofilm formation on the Provox ActiValve: Composition and ingrowth analyzed by Illumina paired-end RNA sequencing, fluorescence in situ hybridization, and confocal laser scanning microscopy. Head & Neck, 38(S1), E432-E440. DOI: 10.1002/hed.24014  [details] 
  • Timmermans, A. J., van Dijk, B. A. C., Overbeek, L. I. H., Velthuysen, M-L. F., van Tinteren, H., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Trends in treatment and survival for advanced laryngeal cancer: a 20-year population-based study in The Netherlands. Head & Neck, 38(S1), E1247-E1255. DOI: 10.1002/hed.24200  [details] 
  • Rebers, S., Vermeulen, E., Brandenburg, A. P., Stoof, T. J., Zupan-Kajcovski , B., Bos, W. J. W., ... Schmidt, M. K. (2016). A randomised controlled trial of consent procedures for the use of residual tissues for medical research: Preferences of and implications for patients, research and clinical practice. PLoS One, 11(3), [e0152509]. DOI: 10.1371/journal.pone.0152509  [details] 
  • Jacobi, I., Navran, A., van der Molen, L., Heemsbergen, W. D., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Radiation dose to the tongue and velopharynx predicts acoustic-articulatory changes after chemo-IMRT treatment for advanced head and neck cancer. European Archives of Oto-Rhino-Laryngology, 273(2), 487-494. DOI: 10.1007/s00405-015-3526-8  [details] 
  • Timmermans, A. J., Lange, C. A. H., de Bois, J. A., van Werkhoven, E., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2016). Tumor volume as a prognostic factor for local control and overall survival in advanced larynx cancer. The Laryngoscope, 126(2), E60-E67. DOI: 10.1002/lary.25567  [details] 
  • van Monsjou, H. S., Schaapveld, M., Hamming-Vrieze, O., de Boer, J. P., van den Brekel, M. W. M., & Balm, A. J. M. (2016). Cause-specific excess mortality in patients treated for cancer of the oral cavity and oropharynx: a population-based study. Oral Oncology, 52, 37-44. DOI: 10.1016/j.oraloncology.2015.10.013  [details] 
  • van Sluis, K. E., van den Brekel, M. W. M., Hilgers, F. J. M., & van Son, R. J. J. H. (2016). Long-Term Stability of Tracheoesophageal Voices. In Interspeech [114]

2015

  • Clapham, R. P., van As-Brooks, C. J., van Son, R. J. J. H., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). The Relationship Between Acoustic Signal Typing and Perceptual Evaluation of Tracheoesophageal Voice Quality for Sustained Vowels. Journal of Voice, 29(4), 517.e23-517.e29. DOI: 10.1016/j.jvoice.2014.10.002  [details] 
  • Hilgers, F. J. M., Dirven, R., Jacobi, I., & van den Brekel, M. W. M. (2015). Physiology and prospects of bimanual tracheoesophageal brass instrument play. Acta Otorhinolaryngologica Italica, 35(3), 202-207. [details] 
  • Kraaijenga, S. A. C., Oskam, I. M., van der Molen, L., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Evaluation of long term (10-years+) dysphagia and trismus in patients treated with concurrent chemo-radiotherapy for advanced head and neck cancer. Oral Oncology, 51(8), 787-794. DOI: 10.1016/j.oraloncology.2015.05.003  [details] 
  • Kraaijenga, S. A. C., van der Molen, L., Jacobi, I., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Prospective clinical study on long-term swallowing function and voice quality in advanced head and neck cancer patients treated with concurrent chemoradiotherapy and preventive swallowing exercises. European Archives of Oto-Rhino-Laryngology, 272(11), 3521-3531. DOI: 10.1007/s00405-014-3379-6  [details] 
  • Kraaijenga, S. A. C., van der Molen, L., Stuiver, M. M., Teertstra, H. J., Hilgers, F. J. M., & van den Brekel, M. (2015). Effects of strengthening exercises on swallowing musculature and function in senior healthy subjects; a prospective effectiveness and feasibility study. Dysphagia, 30(4), 392-403. DOI: 10.1007/s00455-015-9611-8  [details] 
  • Timmermans, A. J., de Gooijer, C. J., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). T3-T4 laryngeal cancer in The Netherlands Cancer Institute: 10-year results of the consistent application of an organ preserving/-sacrificing protocol. Head & Neck, 37(10), 1495-1503. DOI: 10.1002/hed.23789  [details] 
  • van Monsjou, H. S., Schaapveld, M., van den Brekel, M. W. M., & Balm, A. J. M. (2015). The epidemiology of head and neck squamous cell carcinoma in The Netherlands during the era of HPV-related oropharyngeal squamous cell carcinoma: Is there really evidence for a change? Oral Oncology, 51(10), 901-907. DOI: 10.1016/j.oraloncology.2015.06.011  [details] 
  • van den Boer, C., Lansaat, L., Muller, S. H., van den Brekel, M. W. M., & Hilgers, F. J. M. (2015). Comparative ex vivo study on humidifying function of three speaking valves with integrated heat and moisture exchanger for tracheotomised patients. Clinical Otolaryngology, 40(6), 616-621. DOI: 10.1111/coa.12426  [details] 
  • van den Boer, C., Muller, S. H., van der Noort, V., Valdés Olmos, R. A., Minni, A., Parilla, C., ... van der Baan, S. (2015). Effects of heat and moisture exchangers on tracheal mucociliary clearance in laryngectomized patients: a multi-center case-control study. European Archives of Oto-Rhino-Laryngology, 272(11), 3439-3450. DOI: 10.1007/s00405-014-3336-4  [details] 
  • Dohmen, A. J. C., Swartz, J. E., van den Brekel, M. W. M., Willems, S. M., Spijker, R., Neefjes, J., & Zuur, C. L. (2015). Feasibility of primary tumor culture models and preclinical prediction assays for head and neck cancer: A narrative review. Cancers, 7(3), 1716-1742. DOI: 10.3390/cancers7030858 
  • Henneman, R., van Monsjou, H. S., Verhagen, C., van Velhuysen, M. L., ter Haar, N. T., Osse, E. M., ... van den Brekel, M. W. M. (2015). Incidence changes of human papillomavirus in oropharyngeal squamous cell carcinoma and effects on survival in the Netherlands Cancer Institute, 1980-2009. Anticancer research, 35(7), 4015-4022.
  • Lodder, W. L., Vogel, W. V., Lange, C. A., Hamming-Vrieze, O., van Velthuysen, M. L., Pameijer, F. A., ... van den Brekel, M. W. (2015). Detection of extranodal spread in head and neck cancer with [18F]FDG PET and MRI: improved accuracy? The Quarterly Journal of Nuclear Medicine and Molecular Imaging, 59(3), 327-335.
  • Retèl, V. P., van der Molen, L., Steuten, L. M. G., van den Brekel, M. W., & Hilgers, F. J. M. (2015). A cost-effectiveness analysis of using TheraBite in a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy. European Archives of Oto-Rhino-Laryngology, 273(3), 709-718. DOI: 10.1007/s00405-015-3541-9  [details] 
  • Retèl, V. P., van den Boer, C., Steuten, L. M. G., Okła, S., Hilgers, F. J., & van den Brekel, M. W. (2015). Cost-effectiveness of heat and moisture exchangers compared to usual care for pulmonary rehabilitation after total laryngectomy in Poland. European Archives of Oto-Rhino-Laryngology, 272(9), 2381-2388. DOI: 10.1007/s00405-015-3618-5  [details] 
  • Schoot, R. A., Slater, O., Ronckers, C. M., Zwinderman, A. H., Balm, A. J. M., Hartley, B., ... Merks, J. H. M. (2015). Adverse events of local treatment in long term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. European Journal of Cancer, 51(11), 1424-1434. DOI: 10.1016/j.ejca.2015.02.010  [details] 
  • Verhagen, C. V. M., de Haan, R., Hageman, F., Oostendorp, T. P. D., Carli, A. L. E., O'Connor, M. J., ... Vens, C. (2015). Extent of radiosensitization by the PARP inhibitor olaparib depends on its dose, the radiation dose and the integrity of the homologous recombination pathway of tumor cells. Radiotherapy and oncology, 116(3), 358-365. DOI: 10.1016/j.radonc.2015.03.028  [details] 
  • Zerp, S. F., Stoter, T. R., Hoebers, F. J., van den Brekel, M. W. M., Dubbelman, R., Kuipers, G., ... Verheij, M. (2015). Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer. Radiation Oncology, 10, [158]. DOI: 10.1186/s13014-015-0474-9 
  • de Bree, R., & van den Brekel, M. W. M. (2015). Elective neck dissection versus observation in the clinically node negative neck in early oral cancer: Do we have the answer yet? Oral Oncology, 51(11), 963-965. DOI: 10.1016/j.oraloncology.2015.08.013 
  • de Jong, M. C., ten Hoeve, J. J., Grénman, R., Wessels, L. F., Kerkhoven, R., te Riele, H., ... Begg, A. C. (2015). Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients. Clinical Cancer Research, 21(4), 5630-5638. DOI: 10.1158/1078-0432.CCR-15-0454  [details] 
  • de Veij Mestdagh, P. D., van den Brekel, M. W. M., & Smeele, L. (2015). Robotchirurgie bij hoofd-halskanker. Nederlands tijdschrift voor oncologie, 2015(4), 141-147.
  • van Harten, M. C., Hoebers, F. J., Kross, K. W., van Werkhoven, E., van den Brekel, M. W. M., & van Dijk, B. A. (2015). Determinants of treatment waiting times for head and neck cancer in the Netherlands and their relation to survival. Oral Oncology, 51(3), 272-278. DOI: 10.1016/j.oraloncology.2014.12.003 
  • van Loon, J. W. L., Smeele, L. E., Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Outcome of transoral robotic surgery for stage I-II oropharyngeal cancer. European Archives of Oto-Rhino-Laryngology, 272(1), 175-183. DOI: 10.1007/s00405-014-2939-0  [details] 

2014

  • Clapham, R., Middag, C., Hilgers, F., Martens, J-P., van den Brekel, M., & van Son, R. (2014). Developing automatic articulation, voice quality and accent assessment techniques for speakers treated for advanced head and neck cancer. Speech Communication, 59, 44-54. DOI: 10.1016/j.specom.2014.01.003  [details] 
  • Hilgers, F. J. M., van den Boer, C., van den Brekel, M. W. M., & Muller, S. H. (2014). Pulmonary function and rehabilitation. In E. C. Ward, & C. J. van As-Brooks (Eds.), Head and Neck Cancer: Treatment, Rehabilitation and Outcomes. - 2nd ed. (pp. 401-420). San Diego, CA: Plural Publishing. [details] 
  • Timmermans, A. J., Lansaat, L., Kroon, G. V. J., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2014). Early oral intake after total laryngectomy does not increase pharyngocutaneous fistulization. European Archives of Oto-Rhino-Laryngology, 271(2), 353-358. DOI: 10.1007/s00405-013-2524-y  [details] 
  • Timmermans, A. J., Lansaat, L., Theunissen, E. A. R., Hamming-Vrieze, O., Hilgers, F. J. M., & van den Brekel, M. W. M. (2014). Predictive factors for pharyngocutaneous fistulization after total laryngectomy. The Annals of Otology Rhinology & Laryngology, 123(3), 153-161. DOI: 10.1177/0003489414522972  [details] 
  • de Ridder, M., Smeele, L. E., van den Brekel, M. W. M., van Harten, M. C., Wouters, M. W. J. M., & Balm, A. J. M. (2014). Volume criteria for the treatment of head and neck cancer: are they evidence based? Head & Neck, 36(5), 760-762. DOI: 10.1002/hed.23555  [details] 
  • van den Boer, C., Muller, S. H., Vincent, A. D., Züchner, K., van den Brekel, M., & Hilgers, F. J. M. (2014). Ex vivo water exchange performance and short-term clinical feasibility assessment of newly developed heat and moisture exchangers for pulmonary rehabilitation after total laryngectomy. European Archives of Oto-Rhino-Laryngology, 271(2), 359-366. DOI: 10.1007/s00405-013-2528-7  [details] 
  • de Bree, R., van der Putten, L., van Tinteren, H., Wedman, J., Oyen, W. J. G., Janssen, L., ... Leemans, R. (2014). Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial. Radiotherapy and oncology, 118(2), 251-256.
  • van Harten, M. C., de Ridder, M., Hamming-Vrieze, O., Smeele, L. E., Balm, A. J. M., & van den Brekel, M. W. M. (2014). The association of treatment delay and prognosis in head and neck squamous cell carcinoma (HNSCC) patients in a Dutch comprehensive cancer center. Oral Oncology, 50(4), 282-290. DOI: 10.1016/j.oraloncology.2013.12.018  [details] 

2013

  • Clapham, R. P., van As-Brooks, C. J., van den Brekel, M. W. M., Hilgers, F. J. M., & van Son, R. J. J. H. (2013). Automatic tracheoesophageal voice typing using acoustic parameters. Interspeech, 14, 2162-2166. [details] 
  • Hilgers, F. J. M., Lorenz, K. J., Maier, H., Meeuwis, C. A., Kerrebijn, J. D. F., Vander Poorten, V., ... van den Brekel, M. W. M. (2013). Development and (pre-) clinical assessment of a novel surgical tool for primary and secondary tracheoesophageal puncture with immediate voice prosthesis insertion, the Provox Vega Puncture Set. European Archives of Oto-Rhino-Laryngology, 270(1), 255-262. DOI: 10.1007/s00405-012-1976-9  [details] 
  • Timmermans, A. J., Brandsma, D., Smeele, L. E., Rosingh, A. W., van den Brekel, M. W. M., & Lohuis, P. J. F. M. (2013). Cervical osteomyelitis after carbon dioxide laser excision of recurrent carcinoma of the posterior pharyngeal wall. The Annals of Otology Rhinology & Laryngology, 122(4), 273-276. DOI: 10.1177/000348941312200410  [details] 
  • Jacobi, I., van Rossum, M. A., van der Molen, L., Hilgers, F. J. M., & van den Brekel, M. W. M. (2013). Acoustic Analysis of Changes in Articulation Proficiency in Patients With Advanced Head and Neck Cancer Treated With Chemoradiotherapy. The Annals of Otology Rhinology & Laryngology, 122(12), 754-762. DOI: 10.1177/000348941312201205  [details] 
  • Remmelts, A. J., Hoebers, F. J. P., Klop, W. M. C., Balm, A. J. M., Hamming-Vrieze, O., & van den Brekel, M. W. M. (2013). Evaluation of lasersurgery and radiotherapy as treatment modalities in early stage laryngeal carcinoma: tumour outcome and quality of voice. European Archives of Oto-Rhino-Laryngology, 270(7), 2079-2087. DOI: 10.1007/s00405-013-2460-x  [details] 
  • van den Boer, C., Muller, S. H., Vincent, A. D., Züchner, K., van den Brekel, M. W. M., & Hilgers, F. J. M. (2013). A novel, simplified ex vivo method for measuring water exchange performance of Heat and Moisture Exchangers for postlaryngectomy pulmonary rehabilitation. Respiratory Care, 58(9), 1449-1458. DOI: 10.4187/respcare.02369  [details] 
  • van der Molen, L., Kornman, A. F., Latenstein, M. N., van den Brekel, M. W. M., & Hilgers, F. J. M. (2013). Practice of laryngectomy rehabilitation interventions: a perspective from Europe/the Netherlands. Current Opinion in Otalaryngology & Head and Neck Surgery, 21(3), 230-238. DOI: 10.1097/MOO.0b013e3283610060  [details] 

2012

  • Clapham, R. P., van der Molen, L., van Son, R. J. J. H., van den Brekel, M., & Hilgers, F. J. M. (2012). NKI-CCRT corpus: speech intelligibility before and after advanced head and neck cancer treated with concomitant chemoradiotherapy. In N. Calzolari, K. Choukri, T. Declerck, M. Uğur Doğan, B. Maegaard, J. Mariani, J. Odijk, ... S. Piperidis (Eds.), Proceedings of the Eighth International Conference on Language Resources and Evaluation (LREC'12): 23-25 May, 2012, Istanbul, Turkey (pp. 3350-3355). Paris: European Language Resources Association (ELRA). [details] 
  • Hilgers, F. J. M., Dirven, R., Wouters, Y., Jacobi, I., Marres, H. A. M., & van den Brekel, M. W. M. (2012). A multicenter, prospective, clinical trial evaluating a novel adhesive baseplate (Provox StabiliBase) for peristomal attachment of postlaryngectomy pulmonary and voice rehabilitation devices. The Laryngoscope, 122(11), 2447-2453. DOI: 10.1002/lary.23469  [details] 
  • Theunissen, E. A. R., Timmermans, A. J., Zuur, C. L., Hamming-Vrieze, O., de Boer, J. P., Hilgers, F., & van den Brekel, M. W. M. (2012). Total laryngectomy for a dysfunctional larynx after (chemo)radiotherapy. Archives of Otolaryngology Head&Neck Surgery, 138(6), 548-555. DOI: 10.1001/archoto.2012.862  [details] 
  • van den Brekel, M. W. M., Lodder, W. L., Stel, H. V., Bloemena, E., Leemans, C. R., & van der Waal, I. (2012). Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck. Head & Neck, 34(6), 840-845. DOI: 10.1002/hed.21823  [details] 
  • Graveland, A. P., Braakhuis, B. J. M., Eerenstein, S. E. J., de Bree, R., Bloemena, E., de Maaker, M., ... Brakenhoff, R. H. (2012). Molecular diagnosis of minimal residual disease in head and neck cancer patients. Cellular Oncology, 35(5), 367-375. DOI: 10.1007/s13402-012-0097-1  [details] 

2010

  • Hilgers, F. J. M., Ackerstaff, A. H., van Rossum, M., Jacobi, I., Balm, A. J. M., Tan, I. B., & van den Brekel, M. W. M. (2010). Clinical phase I/feasibility study of the next generation indwelling Provox voice prosthesis (Provox Vega). Acta Oto-Laryngologica, 130(4), 511-519. DOI: 10.3109/00016480903283766  [details] 
  • Hilgers, F. J. M., Ackerstaff, A. H., Jacobi, I., Balm, A. J. M., Tan, I. B., & van den Brekel, M. W. M. (2010). Prospective clinical phase II study of two new indwelling voice prostheses (Provox Vega 22.5 and 20 Fr) and a novel anterograde insertion device (Provox Smart Inserter). The Laryngoscope, 120(6), 1135-1143. DOI: 10.1002/lary.20925  [details] 
  • Hilgers, F. J. M., Balm, A. J. M., van den Brekel, M. W. M., & Tan, I. B. (2010). Voice restoration. In M. Remacle, & H. E. Eckel (Eds.), Surgery of larynx and trachea (pp. 245-256). Berlin [etc.]: Springer. [details] 
  • Hilgers, F. J. M., & van den Brekel, M. W. M. (2010). Vocal and speech rehabilitation following laryngectomy. In P. W. Flint, B. H. Haughey, V. J. Lund, J. K. Niparko, M. A. Richardson, K. T. Robbins, & J. R. Thomas (Eds.), Cummings otolaryngology: head & neck surgery. - 5th ed. (pp. 1594-1610). Philadelphia, PA: Mosby Elsevier. [details] 
  • Karakullukcu, M. B., Lohuis, P. J., van den Brekel, M. W. M., & Hilgers, F. J. M. (2010). Sealing of small postlaryngectomy pharyngocutaneous fistulas with voice prosthesis. The Laryngoscope, 120(10), 1971-1973. DOI: 10.1002/lary.21071  [details] 

2008

  • Hilgers, F. J. M., Soolsma, J., Ackerstaff, A. H., Balm, F. J. M., Tan, I. B., & van den Brekel, M. W. M. (2008). A thin tracheal silicone washer to solve periprosthetic leakage in laryngectomies: direct results and long-term clinical effects. The Laryngoscope, 118(4), 640-645. DOI: 10.1097/MLG.0b013e31816067d5  [details] 
  • Hilgers, F. J. M., & van den Brekel, M. (2008). Practical tips for voice rehabilitation after pharyngolaryngectomy. In C. R. Cernea, F. L. Dias, D. Fliss, R. A. Lima, E. N. Myers, & W. I. Wei (Eds.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications (pp. 96-97). Basel [etc.]: Karger. [details] 
  • van den Brekel, M., & Hilgers, F. J. M. (2008). Preoperative workup of the neck in Head and Neck Squamous Cell Carcinoma. In C. R. Cernea, F. L. Dias, D. Fliss, R. A. Lima, E. N. Myers, & W. I. Wei (Eds.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications (pp. 34-35). Basel [etc.]: Karger. [details] 
  • Soolsma, J., van den Brekel, M. W., Ackerstaff, A. H., Balm, A. J., Tan, B., & Hilgers, F. J. (2008). Long-term results of Provox ActiValve, solving the problem of frequent Candida - and 'underpressure'-related voice prosthesis replacements. The Laryngoscope, 118(2), 252-257. DOI: 10.1097/MLG.0b013e318159ebde  [details] 

2007

  • Menger, D. J., van den Brekel, M. W. M., & Hilgers, F. J. M. (2007). Een bijzonder beloop van een glottisch larynxcarcinoom. Nederlands tijdschrift voor Keel- Neus- en Oorheelkunde, 2007(13), 151-154. [details] 

2006

  • Hilgers, F. J. M., Balm, A. J. M., van den Brekel, M. W. M., & Tan, I. B. (2006). Problembehandlung bei der prothetischen Stimmrehabilitation nach (totaler) Laryngektomie. Journal der Deutschen Gesellschaft für Plastische und Wiederherstellungschirurgie, 33, 41-51. [details] 

2016

  • Muller, S. H., van den Brekel, M. W. M., & Hilgers, F. J. M. (2016). Letter to the editor regarding: The effect of cloth stoma covers on tracheal climate of laryngectomy patients. Head & Neck, 38(2), 330-331. DOI: 10.1002/hed.24251  [details] 

2015

  • Paleri, V., Drinnan, M., van den Brekel, M. W. M., Takes, R. P., Rinaldo, A., & Ferlito, A. (2015). In response to Vascularized tissue to reduce fistula following salvage total laryngectomy: a systematic review. The Laryngoscope, 125(4), E156. DOI: 10.1002/lary.25018 

2011

  • Clapham, R., Hilgers, F., van den Brekel, M., & van Son, R. (2011). An exploration into automatic phonological feature evaluation of tracheoesophageal speech. In W. Zonneveld, H. Quené, & W. Heeren (Eds.), Sound and sounds: studies presented to M.E.H. (Bert) Schouten on the occasion of his 65th birthday (pp. 69-79). Utrecht: Utrecht Institute of Linguistics OTS. [details] 
  • Balm, A. J. M., van den Brekel, M. W. M., Tan, I. B., & Hilgers, F. J. M. (2011). The indwelling voice prosthesis for speech rehabilitation after total laryngectomy: a safe approach. Otolaryngologia polska = Polish journal of otolaryngology, 65(6), 402-409. [details] 

2015

  • Hilgers, F. J. M., & van den Brekel, M. W. M. (2015). Vocal and Speech Rehabilitation Following Laryngectomy. In P. W. Flint, B. H. Haughey, V. Lund, J. K. Niparko, K. T. Robbins, J. Regan Thomas, & M. M. Lesperance (Eds.), Cummings Otolaryngology - Head & neck surgery. - 6th ed. - Vol. 2. (pp. 1732-1750). Philadelphia, PA: Elsevier. [details] 
  • Kraaijenga, S. A. C., van den Brekel, M. W. M., Smeele, L. E., & Lapid, O. (2015). Herstel van slik- en stemfunctie met behulp van lipofilling in de mond- of keelholte na behandeling voor hoofd- halskanker. Nederlands Tijdschrift voor Plastische Chirurgie, 6(1), 31-36. [details] 

2013

  • Hilgers, F. J. M., Tan, I. B., & van den Brekel, M. W. M. (in press). Comprehensive (prosthetic) voice, pulmonary and olfaction rehabilitation after total laryngectomy. In Head and Neck Surgery. - 2nd ed.. New Delhi, India: Chris de Souza,Jaypee Brothers Medical Publishers (P) LTD.
  • Hilgers, F. M., Muller, S. H., Scheenstra, R. J., & van den Brekel, M. (2013). Aktuelle Forschung zur Verbesserung der Wärme und Feuchtigkeitskapazität von HME. In K. Lorenz (Ed.), Pulmonale Rehabilitation nach Laryngektomie (pp. 43-52). (UNI-MED science). Bremen: UNI-MED-Verlag. [details] 

2012

  • Hilgers, F. J. M., & van den Brekel, M. (2012). Practical tips for voice rehabilitation after pharyngolaryngectomy. In R. C. Claudio (Ed.), Pearls and pitfalls in head and neck surgery: practical tips to minimize complications. - 2nd ed. (pp. 94-95). Basel: Karger. [details] 
  • Timmermans, A. J., Krap, M., Hilgers, F. J. M., & van den Brekel, M. W. M. (2012). Spraakrevalidatie na een totale laryngectomie. Nederlands Tijdschrift voor Tandheelkunde, 119(7-8), 357-361. DOI: 10.5177/ntvt.2012.07/08.12132  [details] 
  • Timmermans, A. J., van den Brekel, M. W. M., van der Molen, L., Navran, A., Nijssen, T. F., & Hilgers, F. J. M. (2012). Nieuwe ontwikkelingen in behandeling en revalidatie bij hoofd-halskanker. Nederlands Tijdschrift voor Geneeskunde, 156(41), 1719-1724. [A5059]. [details] 
  • Ackerstaff, A., Hilgers, F. M., & van den Brekel, M. (2012). Bedeutung von HME für die ganzheitliche Rehabilitation nach LE. In K. J. Lorenz (Ed.), Pulmonale Rehabilitation nach Laryngektomie (pp. 35-41). (UNI-MED science). Bremen: UNI-MED-Verlag. [details] 

2015

  • Zaim, R., van der Putten, L., de Groot, S., van Tinteren, H., Boers, M., Comans, E. F., ... Uyl-de Groot, C. A. (2015). Recurrent laryngeal carcinoma Pet study (Relaps): Cost analysis of 18f-Fdg Pet in patients with suspected recurrent laryngeal cancer previously treated with radiotherapy. Value in Health, 18(7), A353. DOI: 10.1016/j.jval.2015.09.652 

2012

This list of publications is extracted from the UvA-Current Research Information System. Questions? Ask the library  or the Pure staff  of your faculty / institute. Log in to Pure  to edit your publications.
  • AMC Amsterdam
    KNO arts
  • NKL-AVL Amsterdam
    Hoofd-hals chirurg

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